Monitoring Protein Aggregation and Misfolding

The study of protein aggregation encompasses a broad range of interactions and mechanisms. Many studies into this subject area investigate the aggregation of misfolded proteins, which is thought to be responsible for many degenerative diseases. Since aggregation typically leads to a physical change in protein size, particle size analysis has proven to be a useful experimental technique in this field. Dynamic light scattering (DLS) is now widely used to study protein aggregation as described in this application note.

Webinar on Refractive Index

Please join us for our web-based seminar (or Webinar) Monday May 4 at 1 PM EDT (10 AM PDT) on the importance and determination of refractive index (RI) when using laser diffraction. This is Part III of our Boot Camp Webinar series based on the popular customer training courses of the same name. Topics covered include:

• Defining refractive index (RI)

• The effect RI has on results

• Options for determining RI

• How to deal with the imaginary component

Attending the Webinar is easy and free of charge. We will be glad to help you understand how to attend.

Click to view the invitation to the Webinar on Refractive Index.

Webinar on Setting Rigorous and Practical Particle Size Specifications

Please join us for our web-based seminar (or Webinar) Tuesday May 19 at 1 PM EDT (10 AM PDT) on Setting Particle Size Specifications. This is an updated lecture first presented at the 2005 AAPS meeting, now including additional data and suggestions. Measuring particle size in a production and QC environment can be a monstrous task if the specifications are poorly set. This webinar aims to provide best practice guidelines using, as an example, an active pharmaceutical ingredient. Topics covered include:

• When are specifications required

• FDA and USP regulatory issues

• Dissolution and content uniformity modeling

• Method development and validation

• System verification

• Example and suggested specifications

Attending the Webinar is easy and free of charge. We will be glad to help you understand how to attend.

Click to view the invitation to the Webinar on Setting Particle Size Specifications.

Visit HORIBA at the New York Society of Cosmetic Chemists (NYSCC) Meeting

The annual NY SCC Suppliers Day will be held Tuesday and Wednesday May 12-13 at the New Jersey Convention and Exposition Center at Raritan Center, Edison, New Jersey. HORIBA will display the state of the art LA-950 laser diffraction particle size analyzer and can discuss cosmetic applications in booth 1347. Information about the NJ Expo Center can be found at the website http://www.njexpocenter.com.

Used HORIBA Particle Size Analyzers Can Now Be Bought Through LabX

We continually receive used equipment through trade-ins and turn over of demo systems. In order to facilitate the sale of these used systems we currently have the following instruments advertised on LabX:  LA-910, LA-920, and LB-500. Visit www.labx.com and search for “HORIBA particle size” to find these ads.

Masao Horiba Awards

The 2009 Masao Horiba Award Committe is now accepting applications for consideration.  This year's theme for selection is "Ultrasensitive and Nondestructive Detection of Surface Contamination on Semiconductor and related Materials." 

Please follow this link for more information.